So, nothing good ever comes of SCP idea conjured up while walking around the office, but this one is sticking in my head. Everyone (well, most people at least) knows that caffeine improves blood flow, creating the illusion of banishing fatigue (in actuality, blind studies have shown that a fatigued individual who has partaken of caffeine still suffers from the effects of fatigue, but thinks that their reaction time is back to normal). What if there were a coffee mug which caused caffeine to actually reduce fatigue and/or remove the need for sleep? At first, it seemed like the kind of thing that would write up as an anomalous object, but then it struck me that it might be more interesting if it did so by drawing on vital energy from the drinker, something the Foundation is initially unaware of until someone crunches the data and notices that the test subjects (possibly researchers if this had gotten categorized as "Safe" and allowed for general use as other skips are) were dying earlier than was predicted by actuarial tables. The effect is relatively slight, effectively removing from life expectancy the number of hours of sleep avoided, but it adds up.
I'm sure this has been done before — it seems too obvious an idea — but I figured it was worth appealing to the hive mind over.